Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study

PA Dugue; JK Bassett; EM Wong; JHE Joo; S Li; C Yu; DF Schmidt; E Makalic; NW Doo; DD Buchanan; AM Hodge; DR English; JL Hopper; GG Giles; MC Southey; RL Milne

Journal article

Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study

PA Dugue, JK Bassett, EM Wong, JHE Joo, S Li, C Yu, DF Schmidt, E Makalic, NW Doo, DD Buchanan, AM Hodge, DR English, JL Hopper, GG Giles, MC Southey, RL Milne

Jnci Cancer Spectrum | OXFORD UNIV PRESS | Published : 2021

DOI: 10.1093/jncics/pkaa109

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Abstract

Background: We previously investigated the association between 5 "first-generation"measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study. This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length. Methods: We estimated rate ratios (RRs) for the association between these 3 age-adjusted measures and risk of colorectal (N = 813), gastric (N = 165), kidney (N = 139), lung (N = 327), mature B-cell (N = 423), prostate (N = 846), and urothelial (N = 404) cancer using conditional logistic regression models. We also assessed associations by time since blood draw and b..

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University of Melbourne Researchers

Pierre-Antoine Dugue Author

Eric Joo Author

Shuai Li Author

Daniel Schmidt Author Melbourne School of Population and Global Health

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) grants 1164455. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553, and 504711 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383. S.L. is a Victorian Cancer Agency Early Career Research Fellow (ECRF19020). M.C.S. is an NHMRC Senior Research Fellow (1061177). This work also received funding from Monash University, Melbourne, Australia.